![]() ![]() ![]() Several studies have reported syphilis prevalence and incidence among individuals named in contact investigation studies, primarily in the era before prophylactic treatment of contacts became standard of care. In this paper, we will review the literature on syphilis transmissibility and susceptibility, discuss how prevention efforts can alter syphilis transmission and outline key unanswered questions and areas for future research. 5 Prevention tools, such as condoms, risk-reduction counselling and syphilis screening and treatment, can alter syphilis rates by modifying these key parameters. The rate of spread of syphilis in a population is related to the transmission probability per sexual partnership, the average rate of acquisition of sexual partners and the duration of infectiousness. 3, 4 Understanding the dynamics of syphilis transmission can provide insight into syphilis prevalence and incidence, and inform how to optimise prevention efforts to reduce the incidence of syphilis. 1 Syphilis rates are rising among men who have sex with men (MSM) in the USA, 2 and similar trends in syphilis infections have been reported throughout Europe in cities with large populations of MSM. The global burden of syphilis infection is high, with an estimated 10.6 million incident cases occurring annually. ![]()
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